I am a total layman, so could somebody explain the significance of this study? Obviously those substances alter the brain chemistry, that is not surprising, I think. How are those changes significant? Is there cause for concern?
Please stop posting these pre-clinical studies on rats and mice! No one should ever be taking anything away from these sorts of studies for human health.
The article mentions "cannabis abuse" a few times, what metric is there to put use into the abuse column?
Coffee, weed and plenty of water.
> 100 mg/kg
I don’t know about mice, but for a human, that would be a lot of caffeine.
Maybe more informative is https://www.annualreviews.org/doi/full/10.1146/annurev-nutr-...
Maybe paywalled so I'll emphasize the last sentence of the abstract: "Given the spectrum of conditions studied and the robustness of many of the results, these findings indicate that coffee can be part of a healthful diet."
paper affiliation https://en.wikipedia.org/wiki/Babcock_University
Mac Lethal made a song about it:
What is a vital vs non-vital neurotransmitter? They don't define this in the paper so that term seems totally superfluous.
This paper is useless garbage in terms of telling us anything about humans who consume either or both of these drugs.
Anyone else in the UK unable to access ncbi.nlm.nih.gov? I couldn’t access it yesterday either.
If both can't significantly change neurotransmitters, that would be a splash
Looks like a crap article in a crap journal. In the abstract they refer to cannabis as a stimulant, which seems quite incorrect. Also the results are unsurprising and not very exciting.
The combination is commonly known as Hippie Speedball.
Apathy can mean different things. All psychedelics remove filters to some extent, and Cannabis is no different in this respect. Experiencing your self and your life without filters carries the potential to make it more difficult to keep up appearances.
Nothing has ever done me more good than this combination. My biggest success in work at my current company, a big API-first platform for insurance comparison was built from scratch in 2 weeks time, spent locked inside my apartment, coffee machine running 24/7, a 100mg cookie in the morning and a joint every 2 hours. No one knows.