I think there's a reason so many startups happen in Silicon Valley. The proximity to others in the industry is a huge factor. Grabbing lunch with another startups founder, or a VC, or a mentor, etc. is extremely valuable.
Also, being nomadic makes a good cofounder relationship difficult.
At Fanvibe, we do have an office, but I'm only there 3 or 4 times a week, and I work from coffee shops wherever I can go.
Recently I wrote a quick article about spending a week in Hawaii doing good work.
http://news.ycombinator.com/item?id=1991010