Maybe Polar [0] would suit your needs, I have no idea how it does with TTS. I'm assuming by native you mean "runs on your hardware not a web app". It's native for desktop OSes, not for mobile and they have a syncing service between your devices.

On my iPad I've long been a fan of GoodReader, again I've never tried TTS with it.

[0] http://getpolarized.io/

Check the following threads:

- https://news.ycombinator.com/item?id=24460142

- https://news.ycombinator.com/item?id=24471058

There also is a Python library:

- https://github.com/jsvine/pdfplumber

Native for what platform? Are you on Windows, MacOS, Linux, BSD, iOS, iPadOS, Android, etc. ?

If you are using linux, try Zathura