I don't know how sophisticated the UI has to do, but maybe consider https://htmx.org/ over a SPA.
I've used Django with Django Rest Framework plus Vue with Vuetify in dayjob and it's a pretty productive framework, I did not know any javascript frontend previously so I got quickly to speed with it.
The one you’re already most familiar with.
React and Django are good default options.
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Streamlit (Python)
https://streamlit.io/
Runkit (Javascript)
https://runkit.com/home
Directus (Backend)
https://directus.io/
N8N (Workflows/API/Webhooks)
https://n8n.io/
There are way maaany other low-code / no-code builders with sooner-or-later-hit-by-wall limitations.
It really dependend on what you want to build.
Best luck with your project and curios what you went with.