Axolotls May Hold the Key to Regrowing Limbs

  • I wandered lonely as a clod,

    Just picking up old rags and bottles,

    When onward on my way I plod,

    I saw a host of axolotls;

    Beside the lake, beneath the trees,

    A sight to make a man’s blood freeze.

    //

    Some had handles, some were plain;

    They came in blue, red pink, and green.

    A few were orange in the main;

    The damnedest sight I’ve ever seen.

    The females gave a sprightly glance;

    The male ones all wore knee-length pants.

    //

    Now oft, when on the couch I lie,

    The doctor asks me what I see.

    They flash upon my inward eye

    And make me laugh in fiendish glee.

    I find my solace then in bottles,

    And I forget them axolotls.

         //Mad Magazine, issue 43, 1958 //

  • > That helped them pinpoint a molecule called retinoic acid—a derivative of vitamin A found in many skincare products—as a key ingredient for limb regeneration

    Hoo boy, I am seeing some serious fuel for snake oil, here.

    I wonder how long before I start getting spam selling retinoic acid as an aid in growing ... er, a ... limb ...

    Also, I wonder if the article was edited by AI. That may not be a bad thing, but it would be interesting if The Smithsonian is using AI editors.

  • Here is the paper: https://www.nature.com/articles/s41467-025-59497-5

  • Biologist Michael Levin posits that bio-electric fields “, not simply genes, hold the key to limb regeneration.

    https://youtu.be/VQr9NlWEsPY

  • I wonder how much stress growing a whole limb imply on the body.

    Would it male you prone to get cancer, since all that replication "depleted" our stem cells and brown fat reserves? What about our telomeres?

  • Do we know how a human would regrow a limb? Would it start out as a small limb and grow out or just grow arm first then elbow, forearm, etc.

  • So that's why they named the tech to build gholas after them.

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